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Cholestyramine use with evista is not recommended.

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Because these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

The mean percentage change in BMD from baseline for EVISTA was statistically significantly greater than for placebo at each skeletal sitesee Table 5

Raloxifene is an estrogen agonist/antagonistcommonly referred to as a selective estrogen receptor modulatorSERMThe biological actions of raloxifene are largely mediated through binding to estrogen receptorsThis binding results in activation of estrogenic pathways in some tissuesagonismand blockade of estrogenic pathways in othersantagonismThe agonistic or antagonistic action of raloxifene depends on the extent of recruitment of coactivators and corepressors to estrogen receptorERtarget gene promoters.

EVISTA should be used with caution in patients with moderate or severe renal impairmentSafety and efficacy have not been established in patients with moderate or severe renal impairmentsee CLINICAL PHARMACOLOGY

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