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Th duation o pophylactic administation is dtmind by th duation o th piod at isk.

Pobncid and cimtidin incas th AUC o aciclovi by this mchanism, and duc aciclovi nal claanc. Similaly incass in plasma AUCs o aciclovi and o th inactiv mtabolit o mycophnolat motil, an immunosuppsant agnt usd in tansplant patints hav bn shown whn th dugs a co administd. Howv no dosag adjustmnt is ncssay bcaus o th wid thaputic indx o aciclovi.

Th us o aciclovi should b considd only whn th potntial bnits outwigh th possibility o unknown isks. A post-makting aciclovi pgnancy gisty has documntd pgnancy outcoms in womn xposd to any omulation o Aciclovi. Th gisty indings hav not shown an incas in th numb o bith dcts amongst aciclovi xposd subjcts compad with th gnal population, and any bith dcts showd no uniqunss o consistnt pattn to suggst a common caus. Systmic administation o aciclovi in intnationally accptd standad tsts did not poduc mbyotoxic o tatognic cts in abbits, ats o mic. In a non-standad tst in ats, otal abnomalitis w obsvd but only ollowing such high subcutanous doss that matnal toxicity was poducd. Th clinical lvanc o ths indings is unctain.

Caution is advisd whn administing aciclovi to patints with impaid nal unction. Adquat hydation should b maintaind.

Aciclovi is liminatd pimaily unchangd in th uin via activ nal tubula sction. Any dugs administd concuntly that compt with this mchanism may incas aciclovi plasma concntations.

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a 65-year-old man was given valaciclovir 1 g bd for 36 hours and had reduced concentration and was incoherent.

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