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Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed doseIf you miss taking Clozaril for more than 2 days in a rowcall your doctor before you start taking it again.

Undesirable alterations in lipids have been observed in patients treated with atypical antipsychoticsincluding ClozarilClinical monitoringincluding baseline and periodic follow-up lipid evaluations in patients using clozapineis recommended.

If you miss your doses for longer than a day or twoconsult your doctor for a new schedule to get back to the dose you were onsee Missed Dose sectionUse this medication regularly in order to get the most benefit from itTo help you rememberuse it at the same time(seach day.

Cases have been reported of an interaction between citalopram and clozapinewhich may increase the risk of adverse events associated with clozapineThe nature of this interaction has not been fully elucidated.

Clozaril may enhance the central effects of CNS depressants such as narcoticsantihistamines and benzodiazepinesParticular caution is advised when Clozaril therapy is initiated in patients who are receiving a benzodiazepine or any other psychotropic agentThese patients may have an increased risk of circulatory collapsewhichon rare occasionscan be profound and may lead to cardiac and/or respiratory arrestIt is not clear whether cardiac or respiratory collapse can be prevented by dose adjustment.

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