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It is not known if colchicine capsules are safe and effective for the treatment of:
No dedicated pharmacokinetic study has been conducted using colchicine capsules in patients with varying degrees of renal impairmentColchicine is known to be excreted in urine in humans and the presence of severe renal impairment has been associated with colchicine toxicityUrinary clearance of colchicine and its metabolites may be decreased in patients with impaired renal functionDose reduction or alternatives should be considered for the prophylaxis of gout flares in patients with severe renal impairmentColchicine is not effectively removed by hemodialysisPatients who are undergoing hemodialysis should be monitored carefully for colchicine toxicity.
Colchicine is potentially toxic so it is important not to exceed the dose prescribed by a physician with the necessary knowledge and experience.
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lowering uric acid in the blood to0 quickly will precipate a gout attack, which is a major reason for using pre-dose colchicine and or an anti-inflammatory drug.