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Phenergan can cause side effects that may impair your thinking or reactionsBe careful if you drive or do anything that requires you to be awake and alertAvoid drinking alcoholwhich can increase some of the side effects of PhenerganThere are many other medicines that can interact with promethazineTell your doctor about all the prescription and over-the-counter medications you useThis includes vitaminsmineralsherbal productsand drugs prescribed by other doctorsDo not start using a new medication without telling your doctorKeep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HClConsideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occurRespiratory depressionnightmaresdeliriumand agitated behavior have also been reported in some of these patients.

Treatment of overdosage is essentially symptomatic and supportiveOnly in cases of extreme overdosage or individual sensitivity do vital signsincluding respirationpulseblood pressuretemperatureand EKGneed to be monitoredActivated charcoal orally or by lavage may be givenor sodium or magnesium sulfate orally as a catharticAttention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilationDiazepam may be used to control convulsionsAcidosis and electrolyte losses should be correctedNote that any depressant effects of promethazine HCl are not reversed by naloxoneAvoid analeptics which may cause convulsions.

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