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The benefit of further alterations in lipid levels by the combined use of crestor with fibrates or niacin should be carefully weighed against the potential risks of such combinations.

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CRESTOR therapy should be discontinued if markedly elevated creatine kinase levels occur or myopathy is diagnosed or suspectedCRESTOR therapy should also be temporarily withheld in any patient with an acuteserious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysise.gsepsishypotensiondehydrationmajor surgerytraumasevere metabolicendocrineand electrolyte disordersor uncontrolled seizures

There have been rare reports of immune-mediated necrotizing myopathyIMNMan autoimmune myopathyassociated with statin useIMNM is characterized byproximal muscle weakness and elevated serum creatine kinasewhich persist despite discontinuation of statin treatmentmuscle biopsy showing necrotizing myopathy without significant inflammationimprovement with immunosuppressive agents.

There have been rare reports of immune-mediated necrotizing myopathy associated with statin usesee WARNINGS AND PRECAUTIONS

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as i m sure you probably expected if you ve read the rest of our charming statin profiles, there are a bunch of medications you can t take along with rosuvastatin crestor .

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