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Viramune should only be used with at least two other antiretroviral agentssee section 5.1

For patients less than 3 years and for all other age groupsan immediate-release oral suspension dosage form is availableplease refer to the respective Summary of Product Characteristics

The absorption of nevirapine is not affected by foodantacids or medicinal products which are formulated with an alkaline buffering agent.

Clarithromycin exposure was significantly decreased14-OH metabolite exposure increasedBecause the clarithromycin active metabolite has reduced activity against Mycobacterium avium-intracellulare complex overall activity against the pathogen may be alteredAlternatives to clarithromycinsuch as azithromycin should be consideredClose monitoring for hepatic abnormalities is recommended.

Women of childbearing potential should not use oral contraceptives as the sole method for birth controlsince nevirapine might lower the plasma concentrations of these medicinal productssee sections 4.44.5

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