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The mechanism of action of CELEBREX is believed to be due to inhibition of prostaglandin synthesisprimarily via inhibition of cyclooxygenase-2COX-2

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Because of the risk of disseminated intravascular coagulation with use of CELEBREX in pediatric patients with systemic onset JRAmonitor patients for signs and symptoms of abnormal clotting or bleedingand inform patients and their caregivers to report symptoms as soon as possible.

Tell your healthcare provider about all of the medicines you takeincluding prescription or over-the-counter medicinesvitamins or herbal supplementsNSAIDs and some other medicines can interact with each other and cause serious side effectsDo not start taking any new medicine without talking to your healthcare provider first.

Celecoxib is a potent inhibitor of prostaglandin synthesis in vitroCelecoxib concentrations reached during therapy have produced in vivo effectsProstaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal modelsProstaglandins are mediators of inflammationSince celecoxib is an inhibitor of prostaglandin synthesisits mode of action may be due to a decrease of prostaglandins in peripheral tissues.

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approximately 3,900 patients received celebrex at these doses for 6 months or more; approximately 2,300 of these have received it for 1 year or more and 124 of these have received it for 2 years or more.

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