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Hypersensitivity reactions have been reported with lariam use.

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co-administration of a single 500 mg oral dose of lariam and 600 mg of rifampin once daily for 7 days in 7 healthy thai volunteers resulted in a decrease in the mean c max and auc of lariam by 19 and 68 , respectively, and a decrease in the mean elimination half-life of lariam from 305 hours to 113 hours.

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