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Inform your doctor about all prescribed and over-the-counter medications you are using and especially about the drugs which may interfere with elimination of tolterodine by the liver which include cyclosporine gengraf, neoral, sandimmune , clarithromycin biaxin , azithromycin zithromax , erythromycin, telithromycin ketek , pentamidine nebupent, pentam , sparfloxacin zagam , itraconazole sporanox , ketoconazole nizoral , and miconazole monistat, micatin , arsenic trioxide trisenox , chloroquine arelan or halofantrine halfan , levomethadyl orlaam , or methadone dolophine, methadose , vinblastine velban , medications used to treat psychiatric disorders such aschlorpromazine thorazine , mesoridazine serentil , pimozide orap , haloperidol haldol , or thioridazine mellaril , heart rhythm medicine such as disopyramide norpace , procainamide procan, pronestyl , amiodarone cordarone, pacerone , dofetilide tikosyn , sotalol betapace , quinidine cardioquin, quinaglute .
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In vitro studies with trophozoites of Entamoeba histolytica have demonstrated that chloroquine also possesses amebicidal activity comparable to that of emetine.
Intervention options can involvediazepam for life-threatening symptomsseizures and sedationepinephrine for treatment of vasodilation and myocardial depressionpotassium replacement with close monitoring of serum potassium levels.
Radioactively tagged chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyesIt was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body 2There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant womenUsage of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the potential risk to the fetus.
Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.
Rare reports of erythema multiformeStevens-Johnson syndrometoxic epidermal necrolysisexfoliative dermatitis and similar desquamation-type eventsPleomorphic skin eruptionsskin and mucosal pigmentary changeslichen planus-like eruptionspruritusurticariaanaphylactic/anaphylactoid reaction including angioedemadrug rash with eosinophilia and systemic symptomsDRESS syndromephotosensitivity and hair loss and bleaching of hair pigment.
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the effect of chloroquine may also be related to the formation of a toxic heme-chloroquine complex.